Blar i forfatter "Fabrizius, Andrej"

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    • Transcriptome analysis identifies key metabolic changes in the hooded seal (Cystophora cristata) brain in response to hypoxia and reoxygenation 

      Hoff, Mariana Leivas Müller; Fabrizius, Andrej; Czech-Damal, Nicole U.; Folkow, Lars; Burmester, Thorsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-03)
      The brain of diving mammals tolerates low oxygen conditions better than the brain of most terrestrial mammals. Previously, it has been demonstrated that the neurons in brain slices of the hooded seal (Cystophora cristata) withstand hypoxia longer than those of mouse, and also tolerate reduced glucose supply and high lactate concentrations. This tolerance appears to be accompanied by a shift in the ...

    • Transcriptome analysis reveals a high aerobic capacity in the whale brain 

      Kruger, Alena; Fabrizius, Andrej; Mikkelsen, Bjarni; Siebert, Ursula; Folkow, Lars; Burmester, Thorsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-30)
      The brain of diving mammals is repeatedly exposed to low oxygen conditions (hypoxia) that would have caused severe damage to most terrestrial mammals. Some whales may dive for > 2 h with their brain remaining active. Many of the physiological adaptations of whales to diving have been investigated, but little is known about the molecular mechanisms that enable their brain to survive sometimes ...

    • When the brain goes diving: transcriptome analysis reveals a reduced aerobic energy metabolism and increased stress proteins in the seal brain 

      Fabrizius, Andrej; Hoff, Mariana Leivas Müller; Engler, Gerhard; Folkow, Lars; Burmester, Thorsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-09)
      <b>Background: </b>During long dives, the brain of whales and seals experiences a reduced supply of oxygen (hypoxia). The brain neurons of the hooded seal (Cystophora cristata) are more tolerant towards low-oxygen conditions than those of mice, and also better survive other hypoxia-related stress conditions like a reduction in glucose supply and high concentrations of lactate. Little is known ...